SML3333
Dianhydrogalactitol
≥95% (HPLC)
别名:
1,2:5,6-Dianhydrogalactitol, 1,2:5,6-Diepoxydulcitol, DAG, NSC-132313, VAL-083
InChI key
AAFJXZWCNVJTMK-GUCUJZIJSA-N
InChI
1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2/t3-,4+,5+,6-
SMILES string
O[C@H]([C@@]1(CO1)[H])[C@H]([C@]2(CO2)[H])O
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Blood brain barrier penetrant alkylating agent that causes N7-guanine alkylation
Dianhydrogalactitol is a blood brain barrier penetrant and potent alkylating agent that causes N7-guanine alkylation and inter-strand DNA crosslinks that induces cell cycle arrest followed by apoptosis. Dianhydrogalactitol exhibits potent antitumor activity in number of clinical models including metastatic NSCLC resistant to TKI and glioblastoma multiforme.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Chun Peng et al.
Acta pharmacologica Sinica, 38(4), 561-570 (2017-02-22)
1,2:5,6-dianhydrogalactitol (DAG) is a hexitol epoxide with marked antitumor activity against multiple types of cancer cells, but the molecular mechanisms by which DAG functions as an antitumor agent is largely unknown. In this study, we investigated the inhibitory effects of
Xia Jiang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 91, 1065-1074 (2017-05-21)
The complexity of cancer has led to single-target agents exhibiting lower-than-desired clinical efficacy. Drugs with multiple targets provide a feasible option for the treatment of complex tumors. Multitarget anti-angiogenesis agents are among the new generation of anticancer drugs and have
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