SML3336
VU0155056
≥98% (HPLC)
别名:
5W0, ML272, N-(2-{4-[2-Oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}ethyl)-2-naphthamide, N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide, VU 0155056
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关于此项目
经验公式（希尔记法）:
C25H26N4O2
化学文摘社编号:
分子量:
414.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
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Biochem/physiol Actions
Catalytic site-targeting dual phospholipase D1 & D2 (PLD1 & PLD2) inhibitor.
VU0155056 is a catalytic site-targeting phospholipase D inhibitor (PLD1/PLD2 IC50 = 81 nM/240 nM by cell-free enzymatic assays; substrate = di-palmitoyl-PLC) that effectively suppresses the cellular PLD activity in GFP-PLD2-overexpressing HEK293 cells as well as PMA-stimulated non-small-cell lung cancer (NSCLC) Calu-1 cells with predominant PLD1 activity (IC50 = 380 nM and 21 nM, respectively).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
法规信息
新产品
此项目有
Jeffrey L Barr et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Orexin A, an endogenous peptide involved in several functions including reward, acts via activation of orexin receptors OX1 and OX2, Gq-coupled GPCRs. We examined the effect of a selective OX1 agonist, OXA (17-33) on cytosolic calcium concentration, [Ca2+]i, in neurons
Priyanka Rai et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(49), 12958-12963 (2017-11-22)
Despite massive fluctuations in its internal triglyceride content, the liver secretes triglyceride under tight homeostatic control. This buffering function is most visible after fasting, when liver triglyceride increases manyfold but circulating serum triglyceride barely fluctuates. How the liver controls triglyceride
Amanda R Noble et al.
British journal of cancer, 121(12), 1016-1026 (2019-11-02)
Phospholipases D1 and D2 (PLD1/2) are implicated in tumorigenesis through their generation of the signalling lipid phosphatidic acid and its downstream effects. Inhibition of PLD1 blocks prostate cell growth and colony formation. Here a role for PLD2 in prostate cancer
Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver.
Mukesh Kumar et al.
The Journal of cell biology, 218(11), 3697-3713 (2019-10-13)
Triglyceride-rich lipid droplets (LDs) are catabolized with high efficiency in hepatocytes to supply fatty acids for producing lipoprotein particles. Fasting causes a massive influx of adipose-derived fatty acids into the liver. The liver in the fasted state is therefore bloated
Amanda R Noble et al.
British journal of cancer, 118(2), 189-199 (2017-11-15)
Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastric, kidney
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML3336-25MG | 04065268975060 |
| SML3336-5MG | 04065268975077 |
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