SML3338

NF-56-EJ40

Name: NF-56-EJ40
Brand: SIGMA

≥98% (HPLC)

别名:

2-(2-(4′-((4-Methylpiperazin-1-yl)methyl)biphenyl-3-ylcarboxamido)phenyl)acetic acid, 2-(2-(4′-((4-methylpiperazin-1-yl)methyl)-[1,1′-biphenyl]-3-carboxamido)phenyl)acetic acid, 2-[[[4′-[(4-Methyl-1-piperazinyl)methyl][1,1′-biphenyl]-3-yl]carbonyl]amino]-benzeneacetic acid

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关于此项目

经验公式（希尔记法）:

C₂₇H₂₉N₃O₃

化学文摘社编号:

2380230-73-7

分子量:

443.54

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD32263439

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

High-affinity, human-selective SUCNR1 (GPR91) antagonist that blocks human GPR91-mediated cellular signaling with no activity towards rat species.

NF-56-EJ40 is a high-affinity, potent and human species-selective succinate receptor SUCNR1 (GPR91) antagonist (human GPR91 Ki/KD = 17.4/33 nM; GTPγS assay IC50 = 25 nM/human, >100 μM/rat). Extracellular succinate is reported to hyperpolarize M2 macrophages through GPR91-mediated Gq signaling, blockable by NF-56-EJ40 (1 μM) or Gq inhibitor YM-254890 (1 μM).