SML3341
ML-SA5
≥98% (HPLC)
别名:
N1-(3-Chloro-2-(piperidin-1-yl)phenyl)-N4,N4-dimethylbenzene-1,4-disulfonamide
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关于此项目
经验公式（希尔记法）:
C19H24ClN3O4S2
化学文摘社编号:
分子量:
457.99
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Form:
powder
Assay:
≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
ML-SA5 is a potent TRPML cation channel agonist that activates whole-endolysosomal TRPML1 (ML1) currents in DMD myoblasts at a higher potency than ML-SA1 (EC50 = 285 nM vs 10 μM). ML-SA5 ameliorates muscular dystrophy in mdx, but not ML1-knockout, mice in vivo (2 or 5 mg/kg/day i.p.) by facilitating sarcolemma repair, thereby reducing skeletal and cardiac muscle damage with no apparent toxicity to the animals.
Potent TRPML1 cation channel agonist that ameliorates muscular dystrophy in mdx, but not ML1-KO, mice and with a higher potency than ML-SA1.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable