SML3344
Vosoritide Trifluoroacetate
≥95% (HPLC)
别名:
BMN 111 Trifluoroacetate, PGQEHPNARK YKGANKKGLS KGCFGLKLDR IGSMSGLGC Trifluoroacetate, cyclic (23→39)-disulfide L-prolylglycyl-L-glutaminyl-L-α-glutamyl-L-histidyl-L-prolyl-L-asparaginyl-L-alanyl-L-arginyl-L-lysyl-L-tyrosyl-L-lysylglycyl-Lalanyl-L-asparaginyl-L-lysyl-L-lysylglycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-Cysteine Trifluoroacetate
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C176H290N56O51S3 · xC2HF3O2
分子量:
4102.73 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Biochem/physiol Actions
More stable analogue of human C-type natriuretic peptide (CNP)
Vosoritide is a more stable analogue of human C-type natriuretic peptide (CNP). Vosoritide binds to the Natriuretic-Peptide Receptor B (NPR B), which leads to MAPK pathway inhibition and an increased production of Extracellular Matrix. It reduces the achondroplastic phenotype. Vosoritide is approved for treatment of Achondroplasia aged 5 and up.
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Wiktoria Wrobel et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Achondroplasia (ACH) is a disease caused by a missense mutation in the FGFR3 (fibroblast growth factor receptor 3) gene, which is the most common cause of short stature in humans. The treatment of ACH is necessary and urgent because untreated
Florence Lorget et al.
American journal of human genetics, 91(6), 1108-1114 (2012-12-04)
Achondroplasia (ACH), the most common form of dwarfism, is an inherited autosomal-dominant chondrodysplasia caused by a gain-of-function mutation in fibroblast-growth-factor-receptor 3 (FGFR3). C-type natriuretic peptide (CNP) antagonizes FGFR3 downstream signaling by inhibiting the pathway of mitogen-activated protein kinase (MAPK). Here
Leia C Shuhaibar et al.
JCI insight, 6(9) (2021-05-15)
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in decreased production of cyclic GMP in chondrocytes and severe short stature, causing achondroplasia (ACH) and acromesomelic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML3344-1MG | 04065268085851 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持