SML3354
NRD167
≥98% (HPLC)
别名:
Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate
相关类别
生化/生理作用
Ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor against SIRT5-dependent cancer proliferation and survival.
RD167 is the ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor (IC50 = 370 nM; <10% inhibition of SIRT1/2/3/6 at 10 μM). NRD167 exhibits anti-proliferation (IC50 = 5-8 μM) and apoptosis-induction efficacy (>80% at 5-8 μM) against SIRT5-dependent, but not SIRT5-independent cells. NRD167 selectively impairs proliferation of AML, but not normal hematological progenitors (6.25-12.5 μM; CD34+ cells). Pretreatment of AML patients-derived cells by NRD167 (12.5-25 μM for 72 hrs) prior to xenograft greatly prevents the survival of injected mice.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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