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Merck
CN

SML3359

Sigma-Aldrich

TP-040

≥98% (HPLC)

别名:

N-((1-Methyl-1H-imidazol-4-yl)methyl)-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine

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About This Item

经验公式(希尔记法):
C15H22N6
分子量:
286.38
UNSPSC代码:
51111800
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CC(CC1)CCN1C2=CC=NC(NCC3=CN(C)C=N3)=N2

生化/生理作用

TP-040 is a brain penetrant, potent and selective inhibitor of O-GlcNAcase (OGA). TP-040 increases the level of O-GlcNAcylated protein in cells.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Michiko Tawada et al.
Journal of medicinal chemistry, 64(2), 1103-1115 (2021-01-07)
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokinetic profiles are desirable to characterize this enzyme. Herein, we report

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