质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC(CC1)CCN1C2=CC=NC(NCC3=CN(C)C=N3)=N2
生化/生理作用
TP-040 is a brain penetrant, potent and selective inhibitor of O-GlcNAcase (OGA). TP-040 increases the level of O-GlcNAcylated protein in cells.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Journal of medicinal chemistry, 64(2), 1103-1115 (2021-01-07)
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokinetic profiles are desirable to characterize this enzyme. Herein, we report
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