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关于此项目
经验公式(希尔记法):
C49H60ClN9O8S2
化学文摘社编号:
分子量:
1002.64
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
SMILES string
O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(N3C4=C(C(C5=CC=C(C=C5)Cl)=N2)C(C)=C(S4)C)C)=O)=O)=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C
InChI key
PTAMRJLIOCHJMQ-PYNGZGNASA-N
Biochem/physiol Actions
BRD4 degrader
MZ1 is a BRD4 degrader composed of pan-BET selective bromodomain inhibitor and the E3 ubiquitin ligase VHL ligand that induces preferential degradation of BRD4 over BRD2 and BRD3. MZ1exhibits antiproliferative effects in AML colorectal cancer cells lines.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable