SML3373
BZ194
≥98% (HPLC)
别名:
3-Carboxy-1-[2-(octylamino)-2-oxoethyl]pyridinium bromide, 3-Carboxy-1-octylcarbamoylmethyl-pyridinium bromide, BZ 194, BZ-194
产品名称
BZ194, ≥98% (HPLC)
InChI
1S/C16H24N2O3.BrH/c1-2-3-4-5-6-7-10-17-15(19)13-18-11-8-9-14(12-18)16(20)21;/h8-9,11-12H,2-7,10,13H2,1H3,(H-,17,19,20,21);1H
InChI key
LCFXDNPKEWPCGN-UHFFFAOYSA-N
SMILES string
O=C(C[N+]1=CC(C(O)=O)=CC=C1)NCCCCCCCC.[Br-]
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
BZ194 is a selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to type 1 ryanodine receptor (RYR-1; IC50 ~10 uM against 1 uM NAADP). BZ194 inhibits Ca(2+) mobilization induced by NAADP (IC50 ~3 uM co-injected with 100 nM NAADP into Jurkat T cells), but not Ins(1,4,5)P3 or cyclic ADP-ribose (cADPR), and exhibits no inhibitory potency against capacitative Ca(2+) entry.
Selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to RYR-1 and calcium mobilization.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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