SML3377
BG-3
≥98% (HPLC)
别名:
N-(4-Chlorophenyl)-6-ethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, SID 124738112
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC1=NC2=NC=NN2C(NC3=CC=C(Cl)C=C3)=C1CC
生化/生理作用
BG-3 is a cell penetrant, potent and selective inhibitor of Pax2 (paired-box 2) that inhibits Pax2 transactivation ability. BG-3 inhibit the ability of Pax proteins to recruit PTIP and promote H3K4 methylation at Pax binding sites. BG-3 is not cytotoxic.
cell penetrant, potent and selective inhibitor of Pax2 that inhibits Pax2 transactivation ability
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Shayna T J Bradford et al.
Cell chemical biology, 29(3), 412-422 (2021-11-26)
The Pax family of developmental control genes are frequently deregulated in human disease. In the kidney, Pax2 is expressed in developing nephrons but not in adult proximal and distal tubules, whereas polycystic kidney epithelia or renal cell carcinoma continues to
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