SML3391
Glatiramer acetate
≥95% (HPLC), Myelin basic protein mimetic, powder or Lyophilized powder or film
别名:
Cop 1 (polyamide), Cop-1, Copaxone, Copolymer 1, GA, Polymer with L-alanine, L-lysine, L-tyrosine, and L-glutamic acid acetate
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关于此项目
线性分子式:
(C9H11NO3)a·(C6H14N2O2)b ·(C5H9NO4)c ·(C3H7NO2)d ·x(CH3CO2H)
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Quality level:
Storage condition:
desiccated
产品名称
Glatiramer acetate, ≥95% (HPLC)
InChI
1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1
InChI key
YLOCGHYTXIINAI-XKUOMLDTSA-N
SMILES string
OC([C@@H](N)C)=O.OC(CC[C@H](N)C(O)=O)=O.NCCCC[C@H](N)C(O)=O.OC([C@@H](N)CC1=CC=C(C=C1)O)=O
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to beige
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Glatiramer acetate, a myelin basic protein mimetic, is an immunomodulator used for treatment of Multiple Sclerosis. Glatiramer acetate is a mixture of synthetic peptides randomly composed of glutamic acid, lysine, alanine, and tyrosine. It reduces relapse rate and disease progression in Multiple Sclerosis. Its mechanism of action is not fully understood. Glatiramer acetate generates anti-inflammatory Th2 cells, which produce neurotrophic factors.
Myelin basic protein mimetic; immunodmodulator; used to treat multiple sclerosis; generates anti-inflammatory Th2 cells, which produce neurotrophic factors; promotes neurogenesis
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis
Song JY, Griffin JD, Larson NR, Christopher MA, Middaugh CR, Berkland CJ
Frontiers in Immunology, 11, 603029-603029 (2021)
Glatiramer acetate attenuates depressive/anxiety-like behaviors and cognitive deficits induced by post-weaning social isolation in male mice
Sanusi Andah Salihu , Homanaz Ghafari ,Narges K Gortany
Psychopharmacology, 238, 2121-2132 (2021)
Effects of methylprednisolone and glatiramer acetate on nitric oxide formation of cytokine-stimulated cells from the rat oligodendroglial cell line OLN-93
Christian Holzknecht
Neuroimmunomodulation, 17, 23-30 (2010)
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