SML3394
GZ-11608
≥98% (HPLC)
别名:
4-Methoxy-N-[(1S)-1-methyl-2-phenylethyl]-benzenepropanamine, S-3-(4-Methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine
InChI key
LKTLDVZCNLGHOG-INIZCTEOSA-N
SMILES string
N([C@H](Cc2ccccc2)C)CCCc1ccc(cc1)OC
assay
≥98% (HPLC)
form
oil
color
colorless to brown
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
GZ-11608 is a potent and selective inhibitor of vesicular monoamine transporter-2 (VMAT2) that diminished hERG interaction. GZ-11608 reduces behavioral effects of methamphetamine such as locomotor activity, self-administration, and methamphetamine seeking behavior. It does not exhibit abuse liability. GZ-11608 inhibits methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons.
Potent and selective inhibitor of vesicular monoamine transporter-2 (VMAT2)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Na-Ra Lee et al.
The Journal of pharmacology and experimental therapeutics, 371(2), 526-543 (2019-08-16)
Despite escalating methamphetamine use and high relapse rates, pharmacotherapeutics for methamphetamine use disorders are not available. Our iterative drug discovery program had found that R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-methoxyphenethyl)piperidine hydrochloride (GZ-793A), a selective vesicular monoamine transporter-2 (VMAT2) inhibitor, specifically decreased methamphetamine's behavioral effects. However
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