SML3406
Nutlin-3b
≥98% (HPLC)
别名:
4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone, Nutlin 3b
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关于此项目
经验公式（希尔记法）:
C30H30Cl2N4O4
化学文摘社编号:
分子量:
581.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Nutlin-3b, ≥98% (HPLC)
InChI
1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
SMILES string
ClC(C=C1)=CC=C1[C@@H]2[C@H](C3=CC=C(Cl)C=C3)N(C(N4CCNC(C4)=O)=O)C(C5=C(OC(C)C)C=C(OC)C=C5)=N2
InChI key
BDUHCSBCVGXTJM-IZLXSDGUSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Nutlin-3b, a (+)-enantiomer of Nutlin-3, is a weakly potent antagonist of p53/MDM2 (IC50 = 13.6 μM) that can serve as negative control for Nutlin-3a (IC50 = 90 nM) and other Mdm2 inhibitors.
weakly potent antagonist of p53/MDM2 that can serve as negative control for Nutlin-3a
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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