SML3410
EMD638683
≥98% (HPLC)
别名:
EMD 638683, EMD-638683, N′-[2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide
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关于此项目
经验公式（希尔记法）:
C18H18F2N2O4
化学文摘社编号:
分子量:
364.34
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
CC1=C(C(C(NNC(C(C2=CC(F)=CC(F)=C2)O)=O)=O)=CC=C1O)CC
InChI
1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)
InChI key
SSNAPUUWBPZGOY-UHFFFAOYSA-N
Biochem/physiol Actions
EMD638683 is an orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 3 μM against HeLa cellular NDRG1 phosphorylation) that significantly decreased blood pressure in fructose-treated mice but not in control saline-treated or in SGK1-knockout animals (4460 ppm in chow, ~600 mg/kg/day). EMD638683 promotes radiation-induced suicidal death of CaCo-2 colon tumor cells in vitro (50 μM) and decreases the number of colonic tumors following chemical carcinogenesis in vivo (4460 ppm in chow).
Orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor with anti-cancer and anti-hypertensive efficacy in vitro and in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
An increase in alveolar fluid clearance induced by hyperinsulinemia in obese rats with LPS-induced acute lung injury
Respiratory Physiology & Neurobiology, 279279, 103470-103470 (2020)
SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms
Neurobiology of Disease, 153, 105317-105317 (2021)
EMD638683, a novel SGK inhibitor with antihypertensive potency
Cellular Physiology and Biochemistry, 28(1), 137-146 (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML3410-10MG | 04065268780466 |
| SML3410-50MG | 04065268780473 |