SML3413
ASC-J9
≥98% (HPLC)
别名:
(1E, 4Z, 6E)-5-Hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one, Dimethylcurcumin, GO-Y025
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关于此项目
经验公式（希尔记法）:
C23H24O6
化学文摘社编号:
分子量:
396.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
ASC-J9, ≥98% (HPLC)
InChI
1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-
SMILES string
OC(/C=C/C1=CC(OC)=C(C=C1)OC)=C\C(/C=C/C2=CC(OC)=C(C=C2)OC)=O
InChI key
ZMGUKFHHNQMKJI-CIOHCNBKSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
, White to light orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
ASC-J9 (dimethylcurcumin) is an androgen receptor (AR)-selective degradation promoter that disrupts the interaction between AR and its coregulators. ASC-J9 induces AR degration in cultures (5 µM, LNCaP) and shows in vivo therapeutic efficacy (50 mg/kg i.p. qod) in murine bladder cancer (TCC-SUP and UMUC3 xenografts) and a spinal and bulbar muscular atrophy disease model (AR-polyQ transgenic SBMA mice).
Androgen receptor (AR)-selective degradation promoter in cultures and in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Hao Tian et al.
Journal of experimental & clinical cancer research : CR, 40(1), 3-3 (2021-01-05)
Early studies indicated that ASC-J9®, an androgen receptor (AR) degradation enhancer, could suppress the prostate cancer (PCa) progression. Here we found ASC-J9® could also suppress the PCa progression via an AR-independent mechanism, which might involve modulating the tumor suppressor ATF3
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