SML3420
KY-226
≥97% (HPLC)
别名:
4-((Biphenyl-4-ylmethylthio)methyl)-N-(hexylsulfonyl)benzamide, 4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide, 4-[[([1,1′-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide
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关于此项目
经验公式（希尔记法）:
C27H31NO3S2
化学文摘社编号:
分子量:
481.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)
InChI key
MKXMABKUVSOEJF-UHFFFAOYSA-N
SMILES string
O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
KY-226 is an orally bioavailable, potent and selective allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) that does not function as a PPARg agonist. KY-226 exhibits anti-diabetic, anti-obesity effects by enhancement of insulin and leptin signaling in mice. It appears that KY-226 exerts neuroprotective effects through restoration of phosphorylation of Akt and FoxO1. Thus, it protects BBB integrity by restoration of tight junction (TJ) proteins in mice.
Orally bioavailable, potent and selective allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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