SML3422
Pritelivir
≥98% (HPLC)
别名:
AIC316, BAY 57-1293, BAY57-1293, N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide
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关于此项目
经验公式（希尔记法）:
C18H18N4O3S2
化学文摘社编号:
分子量:
402.49
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
SMILES string
[S](=O)(=O)(N)c1[s]c(nc1C)N(C)C(=O)Cc2ccc(cc2)c3ncccc3
InChI
1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)
InChI key
IVZKZONQVYTCKC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor with antiviral efficacy in cultures and in mice in vivo.
Pritelivir (AIC316; BAY57-1293) is a potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor (IC50 = 30 nM using wt HSV-1F ATPase complex UL5-UL52 & 1 mM ATP) with antiviral efficacy in Vero cultures (replication IC50 = 20 nM against HSV-2G, wt and Acyclovir-resistant HSV-1F; MOI = 0.0025) and in mice in vivo (ED50 = 0.5 mg/kg 3x daily p.o. using HSV-1 Walki or HSV-2 MS), being >28 times more potent than acyclovir and valacyclovir.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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