SML3454

Ridaforolimus

Name: Ridaforolimus
Brand: SIGMA

≥95% (HPLC)

别名:

AP23573, Deforolimus, MK-8669

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关于此项目

经验公式（希尔记法）:

C₅₃H₈₄NO₁₄P

化学文摘社编号:

572924-54-0

分子量:

990.21

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD13184816

主要文件

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InChI

1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

SMILES string

O=C(N1CCCC[C@]12[H])C([C@@]3(O)[C@@H](CC[C@]([H])(O3)C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@H](C([C@@H]([C@H](O)/C(C)=C/[C@H](C(C[C@@]([H])([C@@H](C[C@H]4C[C@@H](OC)[C@@H](CC4)OP(C)(C)=O)C)OC2=O)=O)C)OC)=O)C)C)=O

InChI key

BUROJSBIWGDYCN-GAUTUEMISA-N

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Antiproliferative mTORC1 inhibitor

Ridaforolimus is an antiproliferative mTOR inhibitor that forms a complex with the FK506 binding protein-12 (FKBP-12), which binds to and inhibits mTOR resulting in cell cycle arrest and inhibition of tumor cell growth and proliferation. Like rapamycin, ridaforolimus affects only mTORC1, not mTORC2.