SML3458

KL-11743

Name: KL-11743
Brand: SIGMA

≥98% (HPLC), Class I glucose transporter inhibitor, powder

别名:

2-(3-(6-Ethoxy-4-((4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenyl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide, 2-[3-[6-Ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide

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关于此项目

经验公式（希尔记法）:

C₃₀H₃₀N₆O₃

化学文摘社编号:

1369452-53-8

分子量:

522.60

UNSPSC代码:

12352200

NACRES:

NA.77

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产品名称

KL-11743, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

生化/生理作用

KL-11743 is an orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo. It induces aspartate accumulation and increases mitochondrial metabolism. KL-11743 specifically inhibits the growth of tumors containing truncated the tricarboxylic acid (TCA) cycle due to mutations inactivating succinate dehydrogenase. Inhibition of glucose uptake by KL-11743 may synergize with therapies that induce oxidative stress (synthetic lethality).

orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo