SML3462
IAXO-102 trifluoroacetate salt
≥98% (HPLC)
别名:
IAXO 102 trifluoroacetate salt, Methyl 6-deoxy-6-amino-2,3-di-O-tetradecyl-α-D-glucopyranoside trifluoroacetate salt
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关于此项目
经验公式（希尔记法）:
C35H71NO5 · xC2HF3O2
分子量:
585.94 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77
SMILES string
O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]1CN)OC)OCCCCCCCCCCCCCC)OCCCCCCCCCCCCCC.[xCF3CO2H]
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
IAXO-102 is a potent and selective toll-like receptor 4 (TLR4) antagonist that protect mice from LPS induced septic shock. IAXO-102 inhibits development of an experimental abdominal aortic aneurysm. It also prevents acute BBB disruption after experimental post-subarachnoid hemorrhage in mice.
Potent and selective toll-like receptor 4 (TLR4) antagonist that protect mice from LPS induced septic shock.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.
Piazza M, Rossini C, Della Fiorentina S, Pozzi C, Comelli F, Bettoni I, Fusi P, Costa B, Peri F.
Journal of Medicinal Chemistry (2009)
Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice.
Okada T, Kawakita F, Nishikawa H, Nakano F, Liu L, Suzuki H.
Molecular Neurobiology (2019)
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development.
Huggins C, Pearce S, Peri F, Neumann F, Cockerill G, Pirianov G.
Atherosclerosis (2015)
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