SML3464
Gossypetin
≥98% (HPLC), MKK3 and MKK6 protein kinases inhibitor, powder
别名:
2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one, 8-Hydroxyquercetin, Articulatidin, Equisporol
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关于此项目
经验公式（希尔记法）:
C15H10O8
化学文摘社编号:
分子量:
318.24
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
Gossypetin, ≥98% (HPLC)
InChI
1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H
SMILES string
OC1=CC(O)=C2C(C(O)=C(OC2=C1O)C3=CC=C(C(O)=C3)O)=O
InChI key
YRRAGUMVDQQZIY-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
, light green to yellow
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Antioxidant, antibacterial, anticancer; potent inhibitor of MKK3 and MKK6 protein kinases
Gossypetin is a hexahydroxylated flavonoid found in the flowers and the calyx of Hibiscus, which exhibits numerous pharmacological effects, including antioxidant, antibacterial and anticancer activities. It induces apoptosis and autophagic cell death in prostate cancer cells. Gossypetin is a potent inhibitor of MKK3 and MKK6 protein kinases that suppresses esophageal cancer growth.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Morgana V Araújo et al.
The Analyst, 144(17), 5232-5244 (2019-07-31)
Leishmaniasis comprises a group of infectious diseases with worldwide distribution, of which both the visceral and cutaneous forms are caused by Leishmania parasites. In the absence of vaccines, efficacious chemotherapy remains the basis for leishmaniasis control. The available drugs are
Xiaomeng Xie et al.
Cancer letters, 442, 126-136 (2018-11-06)
Gossypetin as a hexahydroxylated flavonoid found in many flowers and Hibiscus. It exerts various pharmacological activities, including antioxidant, antibacterial and anticancer activities. However, the anticancer capacity of gossypetin has not been fully elucidated. In this study, gossypetin was found to
Ming-Shih Lee et al.
Molecular carcinogenesis, 56(12), 2578-2592 (2017-07-04)
Gossypetin (GTIN), a naturally occurring hexahydroxy flavone, has been shown to possess antimutagenic, antioxidant, antimicrobial, and antiatherosclerotic effects. Here, we investigated the mechanism(s) underlying the anticancer potential of GTIN. In this study, investigations were showed that GTIN preferentially induces programed
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