SMILES string
S1SC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C1)C(=O)N)C(C)C)C)Cc2[nH]cnc2)NC(=O)C
InChI
1S/C22H34N8O6S2/c1-10(2)17-22(36)29-15(18(23)32)7-37-38-8-16(27-12(4)31)21(35)28-14(5-13-6-24-9-25-13)20(34)26-11(3)19(33)30-17/h6,9-11,14-17H,5,7-8H2,1-4H3,(H2,23,32)(H,24,25)(H,26,34)(H,27,31)(H,28,35)(H,29,36)(H,30,33)/t11-,14-,15-,16-,17-/m0/s1
InChI key
FQVLRGLGWNWPSS-BXBUPLCLSA-N
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
ADH-1 is an N-cadherin (CD325; NCAD) antagonist that selectively inhibits NCAD-dependent neurite outgrowth (IC50 = 323 μM; PN1-2 rat cerebral neurons on monolayer of chick NCAD-expressing 3T3), while exhibiting no effect against integrin receptor-dependent neurite outgrowth. ADH-1 inhibits NCAD-mediated signaling events in cultures (0.2-2.5 mg/mL) and exhibits anti-tumor efficacy in vivo (50-100 mg/kg i.p. in rats and mice).
N-cadherin (CD325; NCAD) antagonist that selectively inhibits NCAD-mediated cellular signaling and exhibits anti-tumor efficacy in vivo.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持