SML3473
144DG11
≥98% (HPLC)
别名:
1,2-Dihydro-N-(2-methoxyethyl)-6-methyl-N-[(3-methyl-2-thienyl)methyl]-2-oxo-4-pyridinecarboxamide, 2-Hydroxy-N-(2-methoxyethyl)-6-methyl-N-((3-methylthiophen-2-yl)methyl)isonicotinamide
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder or solid
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder or solid
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
application(s)
research use
storage temp.
2-8°C
SMILES string
OC1=NC(C)=CC(C(N(CCOC)CC2=C(C)C=CS2)=O)=C1
InChI key
BBEZNLRXWCUHAJ-UHFFFAOYSA-N
Biochem/physiol Actions
144DG11 is a polyglucosan (PG)-reducing agent that targets the lysosomal membrane protein LAMP1 and increases autophagic flux in adult polyglucosan body disease (APBD) primary fibroblasts (50 μM for 24 hrs), resulting in an enhanced glycophagy, respiratory and glycolytic ATP production. 144DG11 prolongs survival and improves motor parameters of Gbe(ys/ys) mice in vivo (250 mg/150 μL/kg 2x per wk via i.v. for 1 month, then s.c.), a murine APBD model, by reducing PG and glycogen levels in brain, liver, heart, and peripheral nerve with good pharmacokinetic properties and no adverse effects to the animals.
Polyglucosan (PG)-reducing agent that targets the lysosomal membrane protein LAMP1 in cultures and in vivo.
Disclaimer
For research use only. Not for human use.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable