SML3474
PF-06928215, cis-racemate
≥98% (HPLC)
别名:
Cis-2-(7-Oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3 carboxamido) cyclohexane-1-carboxylic acid, Cis-2-(7-Oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamido)cyclohexanecarboxylic acid, PF-06928215 cis-enantiomers (1R,2S) and (1S,2R)
登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C20H20N4O4
化学文摘社编号:
分子量:
380.40
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
OC([C@H](CCCC1)[C@H]1NC(C2=C3N(N=C2)C(C=C(C4=CC=CC=C4)N3)=O)=O)=O
InChI
1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,22H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1
InChI key
LCOWXYIOVWEZPJ-HIFRSBDPSA-N
Biochem/physiol Actions
PF-06928215 is a high affinity (KD of the (1R,2S) enantiomer = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 μM using the (1R,2S) enantiomer; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-β expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed. Note: this product contains the two cis-enantiomers (1R,2S) and (1S,2R).
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral