SML3479
Hydroxy-α-sanshool
≥95% (HPLC)
别名:
(2E,6Z,8E,10E)-N-(2-Hydroxy-2-methylpropyl)-2,6,8,10-dodecatetraenamide, 2E,6Z,8E,10E-Dodecatetraenoic acid N-(2-hydroxy-2-methylpropyl)amide
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关于此项目
经验公式（希尔记法）:
C16H25NO2
化学文摘社编号:
分子量:
263.38
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
SMILES string
N(CC(O)(C)C)C(=O)\C=C\CC\C=C/C=C/C=C/C
InChI
1S/C16H25NO2/c1-4-5-6-7-8-9-10-11-12-13-15(18)17-14-16(2,3)19/h4-9,12-13,19H,10-11,14H2,1-3H3,(H,17,18)/b5-4+,7-6+,9-8-,13-12+
InChI key
LHFKHAVGGJJQFF-UEOYEZOQSA-N
assay
≥95% (HPLC)
form
powder
storage condition
protect from light, under inert gas
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Hydroxy-α-sanshool is an active ingredient in Szechuan peppers (also present in other Zanthoxylum plants) that produces a tingling paresthesia or numbing effects. Hydroxy-α-sanshool is a potent agonist of TRPV1/TRPA1 as well as antagonist/blocker of KCNK3/KCNK9/KCNK18 channels. It induces colonic motor activity in rat proximal colon.
Potent agonist of TRPV1/TRPA1 as well as antagonist/blocker of KCNK3/KCNK9/KCNK18 channels
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Kunitsugu Kubota et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(7), G579-G590 (2015-01-31)
Various colonic motor activities are thought to mediate propulsion and mixing/absorption of colonic content. The Japanese traditional medicine daikenchuto (TU-100), which is widely used for postoperative ileus in Japan, accelerates colonic emptying in healthy humans. Hydroxy-α sanshool (HAS), a readily
Sanshool on The Fingertip Interferes with Vibration Detection in a Rapidly-Adapting (RA) Tactile Channel
PLoS ONE, 11(12), e0165842-e0165842 (2016)
Diana M Bautista et al.
Nature neuroscience, 11(7), 772-779 (2008-06-24)
In traditional folk medicine, Xanthoxylum plants are referred to as 'toothache trees' because their anesthetic or counter-irritant properties render them useful in the treatment of pain. Psychophysical studies have identified hydroxy-alpha-sanshool as the compound most responsible for the unique tingling
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