SML3483
Dimethylaminoparthenolide
≥98% (HPLC)
别名:
(1aR,4E,7aS,8S,10aS,10bR)-8-[(Dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyloxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, DMAPT
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
C/C1=C\CC[C@](O2)(C)[C@@]2([H])[C@@H](OC([C@@H]3CN(C)C)=O)[C@@]3([H])CC1
InChI key
UJNSFDHVIBGEJZ-SQJADDCJSA-N
相关类别
生化/生理作用
Dimethylaminoparthenolide (DMAPT) is a water-soluble analogue of parthenolide that exhibits anti-inflammatory and anti-tumor activities. It directly binds to ribosomal protein L10 (RPL10) leading to decrease the expression of either p65 or IKKγ in varies pancreatic cancer cells. Dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma (NSCLC) by inhibition of the canonical NF-κB pathway.
Water-soluble analogue of parthenolide that exhibits anti-inflammatory and anti-tumor activities
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
NF-?B inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair.
Cell death discovery, 4, 10-10 (2018)
DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo.
Morel KL, Ormsby RJ, Klebe S, Sweeney CJ, Sykes PJ.
Radiation Research, 192, 231-239 (2019)
Cooperative down-regulation of ribosomal protein L10 and NF-?B signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cells.
Shi C, Wang Y, Guo Y, Chen Y, Liu N.
Oncotarget, 8, 35009-35018 (2017)
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