SML3488
CuATSP
≥98% (HPLC)
别名:
(SP-4-2)-[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]copper, Cu ATSP, Cu-ATSP
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
, Faint brown to dark red
溶解性
DMSO: 2 mg/mL, clear (Warmed)
储存温度
2-8°C
SMILES字符串
CC1=[N]2[Cu]3(SC(NC4=CC=CC=C4)=N2)SC(NC5=CC=CC=C5)=N[N]3=C1C
相关类别
生化/生理作用
CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency.
CuATSP is a CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency (CuATSP/CuATSM IC50 against 150 nM RSL3-induced ferroptosis = 8.5/160 nM using Pfa1 mouse embryonic fibroblasts,16/170 nM using HT-22 mouse hippocampal cells). CuATSP and CuATSM exert their radical-trapping antioxidant (RTA) and (phospho)lipid peroxidation inhibitory potency via an initial reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand, followed by a subsequent H-atom transfer (HAT) that drives the reaction forward.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death.
Zilka O, Poon JF, Pratt DA
Journal of the American Chemical Society, 143, 19043-19057 (2021)
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