SML3490
FMC
≥98% (HPLC)
别名:
Dimethyl(fluoromethyl)(2-hydroxyethyl)ammonium chloride, Fluorocholine chloride, Fluoromethylcholine chloride, N-(Fluoromethyl)-2-hydroxy-n,n-dimethylethanaminium chloride, NSC720948
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关于此项目
经验公式（希尔记法）:
C5H13FNO·Cl
化学文摘社编号:
分子量:
157.61
UNSPSC Code:
41106300
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
(Crystals to semi-solid)
Quality level:
Storage condition:
under inert gas
Quality Level
assay
≥98% (HPLC)
form
(Crystals to semi-solid)
storage condition
under inert gas
color
colorless to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
FC[N+](CCO)(C)C.[Cl-]
InChI
1S/C5H13FNO.ClH/c1-7(2,5-6)3-4-8;/h8H,3-5H2,1-2H3;1H/q+1;/p-1
InChI key
QJEHIIJVWXGJAB-UHFFFAOYSA-M
Biochem/physiol Actions
FMC is a monofluorinated choline that acts as a nonlethal, mechanism-based irreversible inhibtor (pseudosubstrate-based suicide inhibitor) against gut anaerobic bacterial glycyl radical enzyme (GRE) cutC choline trimethylamine (TMA) lyase-catalyzed TMA production from choline (IC50 = 0.9 nM/P. mirabilis & 1.4 nM/D. alaskensis rec. CutC/D) without affecting the bacterial growth (P. mirabilis, E. fergusonii, and P. penneri). A single FMC oral dose (100 mg/kg) to mice on choline-supplemented diet significantly reduces plasma trimethylamine N-oxide (TMAO) level (up to 3 days) as well as diet-induced platelet responsiveness and thrombus formation without toxicity or increased bleeding risk.
Orally active gut bacterial choline trimethylamine (TMA) lyase cutC inhibtor with TMA- & TMA N-oxide (TMAO)-lowering efficacy in vitro and in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Adam B Roberts et al.
Nature medicine, 24(9), 1407-1417 (2018-08-08)
Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks in human clinical studies. TMAO is formed by gut microbe-dependent
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML3490-25MG | 04065268918241 |
| SML3490-100MG | 04065268918234 |