SML3490
FMC
≥98% (HPLC)
别名:
Dimethyl(fluoromethyl)(2-hydroxyethyl)ammonium chloride, Fluorocholine chloride, Fluoromethylcholine chloride, N-(Fluoromethyl)-2-hydroxy-n,n-dimethylethanaminium chloride, NSC720948
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C5H13FNO·Cl
化学文摘社编号:
分子量:
157.61
UNSPSC Code:
41106300
NACRES:
NA.77
MDL number:
产品名称
FMC, ≥98% (HPLC)
SMILES string
FC[N+](CCO)(C)C.[Cl-]
InChI
1S/C5H13FNO.ClH/c1-7(2,5-6)3-4-8;/h8H,3-5H2,1-2H3;1H/q+1;/p-1
InChI key
QJEHIIJVWXGJAB-UHFFFAOYSA-M
assay
≥98% (HPLC)
form
(Crystals to semi-solid)
storage condition
under inert gas
color
colorless to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
FMC is a monofluorinated choline that acts as a nonlethal, mechanism-based irreversible inhibtor (pseudosubstrate-based suicide inhibitor) against gut anaerobic bacterial glycyl radical enzyme (GRE) cutC choline trimethylamine (TMA) lyase-catalyzed TMA production from choline (IC50 = 0.9 nM/P. mirabilis & 1.4 nM/D. alaskensis rec. CutC/D) without affecting the bacterial growth (P. mirabilis, E. fergusonii, and P. penneri). A single FMC oral dose (100 mg/kg) to mice on choline-supplemented diet significantly reduces plasma trimethylamine N-oxide (TMAO) level (up to 3 days) as well as diet-induced platelet responsiveness and thrombus formation without toxicity or increased bleeding risk.
Orally active gut bacterial choline trimethylamine (TMA) lyase cutC inhibtor with TMA- & TMA N-oxide (TMAO)-lowering efficacy in vitro and in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Adam B Roberts et al.
Nature medicine, 24(9), 1407-1417 (2018-08-08)
Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks in human clinical studies. TMAO is formed by gut microbe-dependent
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持