登录并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
, Dark green to black
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C[C@H](NC(C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3N/C(C(C=C)=C\3C)=C\C4=N/C(C(CC)=C4C)=C\C5=C(C(C(O[Na])=O)=C1N5)C)=N\2)=O)C(O[Na])=O)O[Na]
Biochem/physiol Actions
Cancer tissue-targeting photosensitizer that induces irradiation-dependent cancer killing and in vivo photodynamic therapy (PDT) efficacy.
Talaporfin is a chlorin based cancer tissue-targeting photosensitizer that, upon irradiation, generates reactive oxygen species (ROS) that cause DNA damage and apoptosis in cancer cells. Talaporfin induces irradiation-dependent cancer killing in cultures (24 h 10-100 μg/mL Talaporfin sodium followed by washing and 664 nm laser irradation at 15 mW/cm2 and 10 J/cm2; ESCC) and displays photodynamic therapy (PDT) efficacy in human cancer exnograft models in mice in vivo, including EMT-6 sarcoma (100% cure with 664 nm laser at 100 J/cm2 and 100 mw/cm2 24h after 8 mg/kg talaporfin i.p.) and ESCC (664 nm, 100 J/cm2 2h after 10 mg/kg talaporfin sodium via tail vein i.v.).
Talaporfin is a chlorin based cancer tissue-targeting photosensitizer that, upon irradiation, generates reactive oxygen species (ROS) that cause DNA damage and apoptosis in cancer cells. Talaporfin induces irradiation-dependent cancer killing in cultures (24 h 10-100 μg/mL Talaporfin sodium followed by washing and 664 nm laser irradation at 15 mW/cm2 and 10 J/cm2; ESCC) and displays photodynamic therapy (PDT) efficacy in human cancer exnograft models in mice in vivo, including EMT-6 sarcoma (100% cure with 664 nm laser at 100 J/cm2 and 100 mw/cm2 24h after 8 mg/kg talaporfin i.p.) and ESCC (664 nm, 100 J/cm2 2h after 10 mg/kg talaporfin sodium via tail vein i.v.).
Disclaimer
Hygroscopic
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable