SML3520
Talaporfin sodium
≥95% (HPLC)
别名:
Aspartyl chlorin tetrasodium, LS11 tetrasodium, ME 2906 tetrasodium, ME2906 tetrasodium, Mono-L-aspartyl chlorin tetrasodium, Mono-L-aspartyl chlorin e6 tetrasodium, NPe6 tetrasodium, Talaporfin tetrasodium, N-[[(7S,8S)-3-Carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid, tetrasodium salt
质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
desiccated
颜色
, Dark green to black
溶解性
H2O: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
O=C(C[C@H](NC(C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3N/C(C(C=C)=C\3C)=C\C4=N/C(C(CC)=C4C)=C\C5=C(C(C(O[Na])=O)=C1N5)C)=N\2)=O)C(O[Na])=O)O[Na]
生化/生理作用
Cancer tissue-targeting photosensitizer that induces irradiation-dependent cancer killing and in vivo photodynamic therapy (PDT) efficacy.
Talaporfin is a chlorin based cancer tissue-targeting photosensitizer that, upon irradiation, generates reactive oxygen species (ROS) that cause DNA damage and apoptosis in cancer cells. Talaporfin induces irradiation-dependent cancer killing in cultures (24 h 10-100 μg/mL Talaporfin sodium followed by washing and 664 nm laser irradation at 15 mW/cm2 and 10 J/cm2; ESCC) and displays photodynamic therapy (PDT) efficacy in human cancer exnograft models in mice in vivo, including EMT-6 sarcoma (100% cure with 664 nm laser at 100 J/cm2 and 100 mw/cm2 24h after 8 mg/kg talaporfin i.p.) and ESCC (664 nm, 100 J/cm2 2h after 10 mg/kg talaporfin sodium via tail vein i.v.).
Talaporfin is a chlorin based cancer tissue-targeting photosensitizer that, upon irradiation, generates reactive oxygen species (ROS) that cause DNA damage and apoptosis in cancer cells. Talaporfin induces irradiation-dependent cancer killing in cultures (24 h 10-100 μg/mL Talaporfin sodium followed by washing and 664 nm laser irradation at 15 mW/cm2 and 10 J/cm2; ESCC) and displays photodynamic therapy (PDT) efficacy in human cancer exnograft models in mice in vivo, including EMT-6 sarcoma (100% cure with 664 nm laser at 100 J/cm2 and 100 mw/cm2 24h after 8 mg/kg talaporfin i.p.) and ESCC (664 nm, 100 J/cm2 2h after 10 mg/kg talaporfin sodium via tail vein i.v.).
免责声明
Hygroscopic
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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