SML3530
DMA-135
≥98% (HPLC)
别名:
3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-2-pyrazinecarboxamide hydrochloride
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CN(C1=C(N=C(C(N)=N1)C(NC(N)=N)=O)C#CC2=CC=CC=C2)C.[xHCl]
相关类别
生化/生理作用
Cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71
DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Also, previous data indicate that DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR
MedChemComm, 8(5), 1022-1036 (2017)
IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
Nature Communications, 11(1), 4775-4775 (2020)
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