SML3539
MS177
≥98% (HPLC)
别名:
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(6-(4-(2-(3-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4- yl)amino)ethoxy)propanamido)ethyl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-1H- indazole-4-carboxamide
SMILES string
O=C(NCC1=C(C=C(NC1=O)C)C)C2=CC(C3=CC=C(N=C3)N4CCN(CC4)CCNC(CCOCCNC5=CC=CC(C(N6C(C(N7)=O)CCC7=O)=O)=C5C6=O)=O)=CC8=C2C=NN8C(C)C
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell penetrant and potent PROTAC degrader of EZH2 that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes
MS177 is a cell penetrant and potent PROTAC degrader of EZH2 (enhancer of zeste homologue 2) that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 is fast-acting suppressor of cancer growth. MS177 comprises pomalidomide conjugated to a potent EZH2 inhibitor C24 via a short polyethylene glycol linker. It is much more effective and potent in suppressing cancer growth than catalytic inhibitors of EZH2.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Nature Cell Biology, 24, 384-399 (2022)
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