SML3541
KM04794
≥95% (HPLC)
别名:
3-(Trifluoromethyl)benzoic acid 2-[2-[2-[[(4-chlorophenyl)methyl]thio]phenoxy]acetyl]hydrazid
InChI
1S/C23H18ClF3N2O3S/c24-18-10-8-15(9-11-18)14-33-20-7-2-1-6-19(20)32-13-21(30)28-29-22(31)16-4-3-5-17(12-16)23(25,26)27/h1-12H,13-14H2,(H,28,30)(H,29,31)
InChI key
CTHFEQURMFRYPT-UHFFFAOYSA-N
SMILES string
O=C(NNC(C1=CC=CC(C(F)(F)F)=C1)=O)COC2=CC=CC=C2SCC3=CC=C(Cl)C=C3
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell penetrant and potent a chemical chaperone-like modulator of endoplasmic reticulum proteostasis that alleviates ER stress.
KM04794 is a cell penetrant and potent a chemical chaperone-like modulator of endoplasmic reticulum proteostasis that alleviates ER stress. It prevents protein aggregation and cell death caused by ER stressors (such as thapsigargin and dithiothreitol) and a mutant insulin. KM04794 enhances insulin production in pancreatic β cells. Apparently it binds directly to ER molecular chaperone BiP (binding immunoglobulin protein).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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