SML3550
PAIR1
≥98% (HPLC)
别名:
(S)-2,2,2-trifluoro-N-(4-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)ethane-1-sulfonamide
InChI
1S/C26H25F3N6O3S/c27-26(28,29)16-39(36,37)35-22-9-10-23(19-7-2-1-6-18(19)22)38-24-20(8-4-13-31-24)21-11-14-32-25(34-21)33-17-5-3-12-30-15-17/h1-2,4,6-11,13-14,17,30,35H,3,5,12,15-16H2,(H,32,33,34)/t17-/m0/s1
InChI key
LVBYPSVRFGNRPW-KRWDZBQOSA-N
SMILES string
O=S(NC(C=C1)=C2C(C=CC=C2)=C1OC3=NC=CC=C3C4=CC=NC(N[C@@H]5CNCCC5)=N4)(CC(F)(F)F)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell penetrant, potent and selective ATP-competitive partial antagonist of the IRE1α RNase activity, while affording quantitative kinase activity inhibition
PAIR1 is a cell penetrant, potent and selective ATP-competitive partial antagonist of the IRE1α (endoplasmic reticulum to nucleus signaling 1) RNase activity, while affording quantitative kinase activity inhibition. PAIR1 partially antagonize the IRE1α RNase at full occupancy of the kinase. In β-cells PAIR1 allows adaptive splicing of Xbp1 mRNA while suppressing destructive ER mRNA endonucleolytic decay and apoptosis.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Hannah C Feldman et al.
Nature chemical biology, 17(11), 1148-1156 (2021-09-25)
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate dichotomy is promoted by differential activation of the ER transmembrane
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