SML3560
MU380
≥98% (HPLC)
别名:
(R)-6-bromo-5-(piperidin-3-yl)-3-(1-(trifluoromethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine; 6-Bromo-5-(3R)-3-piperidinyl-3-[1-(trifluoromethyl)-1H-pyrazol-4-yl]-pyrazolo[1,5-a]pyrimidin-7-amine
SMILES string
NC1=C(C([C@@]2([H])CNCCC2)=NC3=C(C=NN13)C4=CN(N=C4)C(F)(F)F)Br
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
MU380 is a metabolically stable analog of CHK1 inhibitor SCH900776 (MK8776) does not undergo in vivo N-dealkylation. MU380 is a potent and selective CHK1 inhibitor, which potently sensitizes multiple cancer cell lines to DNA antimetabolites including hydroxyurea, cytarabine and gemcitabine.
Metabolically stable, potent and selective CHK1 inhibitor
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
Pounami Samadder, Fedor Nikulenkov, Hana Kolarova
Molecular Cancer Therapeutics, 16, 1831-1842 (2017)
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe
Molecular Oncology, 14, 2487-2503 (2020)
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells
Haematologica, 104, 2443-2455 (2019)
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