InChI
1S/C23H21N5OS/c1-2-6-19-16(4-1)12-20(29-19)18-14-30-23(26-18)15-7-10-28(11-8-15)13-21-25-17-5-3-9-24-22(17)27-21/h1-6,9,12,14-15H,7-8,10-11,13H2,(H,24,25,27)
InChI key
JOCPQSJABURDDD-UHFFFAOYSA-N
SMILES string
C12=C(C=CC=N2)NC(CN3CCC(CC3)C4=NC(C5=CC6=CC=CC=C6O5)=CS4)=N1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell penetrant, in vivo suitable, potent, selective, and species cross-reactive Complex I inhibitor
Complex 1 probe BAY-179 is a cell penetrant, in vivo suitable, potent, selective, and species cross-reactive Complex I inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jeffrey Mowat et al.
ACS medicinal chemistry letters, 13(3), 348-357 (2022-03-19)
Mitochondria are key regulators of energy supply and cell death. Generation of ATP within mitochondria occurs through oxidative phosphorylation (OXPHOS), a process which utilizes the four complexes (complex I-IV) of the electron transport chain and ATP synthase. Certain oncogenic mutations
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