InChI key
OXFXDOLAQBMOPH-UHFFFAOYSA-N
SMILES string
O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cysteine reactive UBE2D/NFKB1 molecular glue degrader; NFKB1 molecular glue degrader
EN450 is a molecular glue degraders of the oncogenic transcription factor NFKB1 that induces ternary complex formation between ubiquitin-conjugating enzyme E2D1 (UBE2D1) and NFKB1. EN450 covalently modifies an allosteric C111 in UBE2D1 and significantly reduces NFKB1 p105 levels. It impairs leukemia cell viability in a NEDDylation and proteasome-dependent manner at 50 µM.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-?B
bioRxiv : the preprint server for biology (2022)
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