SML3583
PF-04634817 succinate
≥98% (HPLC)
别名:
1,5-Anhydro-2,3-dideoxy-4-O-methyl-3-[[(1R,3S)-3-(1-methylethyl)-3-[[(1S,4S)-5-[6-(trifluoromethyl)-4-pyrimidinyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]carbonyl]cyclopentyl]amino]-D-erythro-pentitol succinate
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选择尺寸
关于此项目
经验公式（希尔记法）:
C25H36F3N5O3 · C4H6O4
化学文摘社编号:
分子量:
629.67
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
InChI key
MCRWZBYTLVCCJJ-DKALBXGISA-N
SMILES string
CO[C@H]1[C@@H](N[C@@H]2CC[C@@](C(N3C[C@@]4([H])N(C5=NC=NC(C(F)(F)F)=C5)C[C@]3([H])C4)=O)(C(C)C)C2)CCOC1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
Orally available, potent and selective CCR2/5 receptor antagonist
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Identification of Molecular Signatures and Candidate Drugs in Vascular Dementia by Bioinformatics Analyses
Shu J, Wei W, Zhang L
Frontiers in Molecular Neuroscience, 15, 751044-751044 (2022)
Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy
Gale JD, Gilbert S, Blumenthal S, Elliott T, Pergola PE, Goteti K, Scheele W, Perros-Huguet C
Kidney international reports, 3, 1316-1327 (2018)
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