SML3585
PSB-CB5
≥98% (HPLC)
别名:
5H-Imidazo[2,1-b][1,3]thiazin-3(2H)-one, 2-[[3-[(4-chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-, (2Z)
InChI key
XJBQRMOGMULGPP-PDGQHHTCSA-N
SMILES string
O=C1N2C(SCCC2)=N/C1=C\C3=CC(OCC4=CC=C(C=C4)Cl)=CC=C3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
PSB-CB5 is a potent and selective GPR18 antagonist that inhibits Δ9-THC-induced GPR18 β-arrestin recruitment (IC50 = 279 nM; [THC] = EC50 = 7.5 μM) with no potency against human GPR55 (IC50 >10 μM) and little or no affinity toward human CB2 and CB1 (Ki = 4.03 μM & >10 μM, respectively).
Potent and selective GPR18 antagonist with little or no potency towrd human GPR55, CB1 or CB2.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating
Pharmaceuticals (Basel, Switzerland), 14(3), 270-270 (2021)
Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55
MedChemComm, 5(5), 632-649 (2014)
Douglas J Hermes et al.
Experimental neurology, 341, 113699-113699 (2021-03-20)
Human immunodeficiency virus type 1 (HIV-1) is known to provoke microglial immune responses which likely play a paramount role in the development of chronic neuroinflammatory conditions and neuronal damage related to HIV-1 associated neurocognitive disorders (HAND). In particular, HIV-1 Tat
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