SML3598
1PBC
≥98% (HPLC)
别名:
1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile
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关于此项目
经验公式（希尔记法）:
C13H6F3N3O
化学文摘社编号:
分子量:
277.20
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
产品名称
1PBC, ≥98% (HPLC)
form
powder
color
white to beige
SMILES string
OC1=CC(C(F)(F)F)=C(C#N)C2=NC3=CC=CC=C3N21
assay
≥98% (HPLC)
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Potent and selective blocker of TMEM16A calcium-activated chloride channel; potent inhibitor of TMEM16F channel
1PBC is a potent and selective blocker of TMEM16A calcium-activated chloride channel that interacts with the anion pore. Also, 1PBC is a potent inhibitor of TMEM16F channel.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Identification of a conserved drug binding pocket in TMEM16 proteins
Research square (2022)
Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC
Lam AKM, Rutz S, Dutzler R
Nature Communications, 13, 2798-2798 (2022)
Christian J Peters et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3547-3552 (2015-03-04)
TMEM16A (transmembrane protein 16) (Anoctamin-1) forms a calcium-activated chloride channel (CaCC) that regulates a broad array of physiological properties in response to changes in intracellular calcium concentration. Although known to conduct anions according to the Eisenman type I selectivity sequence
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