SML3601
ZZW-115 trihydrochloride
≥98% (HPLC)
别名:
10-[3-[4-[2-(Dimethylamino)ethyl]-1-piperazinyl]propyl]-2-(trifluoromethyl)phenothiazine trihydrochloride, N,N-Dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanamine trihydrochloride, ZZW 115 trihydrochloride, ZZW115 trihydrochloride
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (Warmed)
储存温度
2-8°C
SMILES字符串
FC(F)(C1=CC=C2SC3=C(N(CCCN4CCN(CC4)CCN(C)C)C2=C1)C=CC=C3)F.[3HCl]
相关类别
生化/生理作用
Nuclear protein 1 (NUPR1) inhibitor that suppresses NUPR1-dependent cancer growth in vitro and in vivo via necroptosis and ferroptosis induction.
ZZW-115 is a nuclear protein 1 (NUPR1) inhibitor that suppresses NUPR1-dependent cancer growth in vitro (IC50 from 0.84 μM/ANOR to 4.93 μM/HN14 among 11 pancreatic ductal adenocarcinoma cultures) and in mice in vivo (5 mg/kg q.d. or q.a.d. via i.p.) via necroptosis and ferroptosis induction. ZZW-115 blocks importins-mediated NUPR1 nuclear translocation by directly targeting NUPR1 nuclear location signal (NLS) region (Kd = 2.1 μM by calorimetric titration).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Patricia Santofimia-Castaño et al.
Cells, 8(11) (2019-11-21)
Cancer cells activate stress-response mechanisms to adapt themselves to a variety of stressful conditions. Among these protective mechanisms, those controlled by the stress-induced nuclear protein 1 (NUPR1 ) belong to the most conserved ones. NUPR1 is an 82-residue-long, monomeric, basic
Patricia Santofimia-Castaño et al.
The Journal of clinical investigation, 129(6), 2500-2513 (2019-03-29)
Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their prevalence in various diseases including cancer. Drug development targeting IDPs is challenging because they have dynamical structure features and conventional drug design is not applicable. NUPR1
Wenjun Lan et al.
Cancer letters, 486, 8-17 (2020-05-25)
HCC is a highly lethal malignancy with Sorafenib as the only molecularly targeted drug. The multifunctional stress-associated protein, NUPR1, plays an essential role in controlling cell growth, migration, invasion and Sorafenib resistance in HCC. We report here that NUPR1 expression
Jiao Liu et al.
Nature communications, 12(1), 647-647 (2021-01-30)
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive. Using NanoString technology, we identify NUPR1, a stress-inducible
Wenjun Lan et al.
JCI insight, 5(18) (2020-08-12)
Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO pathway. We demonstrated that
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持