SML3606
Nosiheptide
≥97% (HPLC)
别名:
Multhiomycin, N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endothiazolomethanimino)-4-thiazolecarboxamide, NSC 307240, RP 9671
选择规格
关于此项目
Quality Segment
assay
≥97% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to beige
storage temp.
-10 to -25°C
SMILES string
[s]1c(nc(c1)C(=O)NC(=C)C(=O)N)c2nc3c(cc2O)c4[s]cc(n4)C(=O)NC(C(=O)NC(=CC)c5[s]cc(n5)C(=O)NC6CC(C(=O)OCc7c8c([nH]c(c8C)C(=O)SCC(NC(=O)c%10nc6[s]c%10)c9[s]cc3n9)ccc7)O)C(O)C
InChI
1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(1
InChI key
OQAOHXRUMXWDLQ-UHFFFAOYSA-N
Biochem/physiol Actions
Nosiheptide is a thiopeptide antibiotic effective against Gram-positive bacteria with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). It is inactive against most Gram-negative bacteria. Nosiheptide inhibits bacterial ribosomal protein synthesis by binding to the 50S ribosomal subunit blocking the binding region of elongation factor. It is not approved as an antibiotic for human use, but has found veterinary use in feed as an animal growth promoter.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable