SML3609
Sulthiame
≥95% (HPLC)
别名:
4-(1,1-Dioxothiazinan-2-yl)benzenesulfonamide, 4-(Tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-benzenesulfonamide, 4-sulfamoyl-phenyl-[1,2]thiazinane-1,1-dioxide, Sultiame
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
NS(C1=CC=C(N2CCCCS2(=O)=O)C=C1)(=O)=O
InChI
1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)
InChI key
HMHVCUVYZFYAJI-UHFFFAOYSA-N
生化/生理作用
Carbonic anhydrase inhibitor with in vivo anticonvulsant (antiepileptic) efficacy.
Sulthiame is a carbonic anhydrase (CA) inhibitor (hCA Ki in nM = 374/I, 7/II, 95/IV, 81/VA, 91/VB, 134/VI, 6/VII, 43/IX, 56/XII; Ki = 630 mM/hCA III, 1.45 μM/mCA XIII, 1.54 μM/hCA XIV) with anticonvulsant efficacy in vivo.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Claudia Temperini et al.
Bioorganic & medicinal chemistry letters, 17(17), 4866-4872 (2007-06-26)
Sulthiame, a clinically used antiepileptic, was investigated for its interaction with 12 catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The drug is a potent inhibitor of CA II, VII, IX, and XII (K(I)s of 6-56 nM), and a
Comparison of the Sulfonamide Inhibition Profiles of the ?- and ?-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei
Molecules (Basel), 22(3), 421-421 (2017)
Tobias Leniger et al.
Epilepsia, 43(5), 469-474 (2002-05-25)
Sulthiame is a carbonic anhydrase (CA) inhibitor with an anticonvulsant effect in the treatment of benign and symptomatic focal epilepsy in children. The aim of the study was to elucidate the mode of action of sulthiame with respect to possible
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