SML3612
Ganoderic acid D
≥95% (HPLC)
别名:
(7β)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid, GAD
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关于此项目
经验公式（希尔记法）:
C30H42O7
化学文摘社编号:
分子量:
514.65
UNSPSC Code:
12352106
NACRES:
NA.21
MDL number:
SMILES string
O[C@H]1C[C@@H]2[C@](CCC(=O)C2(C)C)(C3=C1[C@]4([C@@]([C@H](CC4=O)[C@@H](CC(=O)CC(C)C(=O)O)C)(CC3=O)C)C)C
InChI key
YTVGSCZIHGRVAV-IYAQLQCNSA-N
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Ganoderic acid D is one of major triterpenes isolated from Ganoderma lucidum that exhibit potent anticancer properties. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate, and pyruvate and acetyl-coenzyme production through SIRT3 upregulation via acetylated cyclophilin D inhibition.
Major triterpenes isolated from Ganoderma lucidum that exhibit potent anticancer properties
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Zhendong Liu et al.
European journal of pharmacology, 824, 72-77 (2018-01-29)
Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid. This study aims to assess the effects of GAD on the energy metabolism of colon cancer through the regulation of SIRT3 expression and whether this effect is related to acetylated
Ruo-Lin Zhao et al.
Journal of ethnopharmacology, 210, 287-295 (2017-09-09)
Ganoderma lucidum (GL) is an oriental medical fungus, which was used to prevent and treat many diseases. Previously, the effective compounds of Ganoderma lucidum extract (GLE) were extracted from two kinds of GL, [Ganoderma lucidum (Leyss. Ex Fr.) Karst.] and
Qing-Xi Yue et al.
Molecular & cellular proteomics : MCP, 7(5), 949-961 (2008-01-02)
Triterpenes isolated from Ganoderma lucidum could inhibit the growth of numerous cancer cell lines and were thought to be the basis of the anticancer effects of G. lucidum. Ganoderic acid D (GAD) is one of the major components in Ganoderma
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