SML3616
Kazinol U
≥95% (HPLC)
别名:
(+)-Kazinol U, 4-[(2S)-3,4-Dihydro-7-hydroxy-2H-1-benzopyran-2-yl]-3-(3-methyl-2-buten-1-yl)-1,2-benzenediol
生化/生理作用
Anti-melanogenic in mouse and human melanoma cells through the induction of AMPK and MAPK phosphorylation
Kazinol U is prenylated flavan isolated from an extract of Broussonetia kazinoki Sieb (paper mulberry) that exhibits anti-melanogenic activity in mouse and human melanoma cells through the induction of AMPK and MAPK phosphorylation. Kazinol U inhibits tyrosinase activity and melanin synthesis through the reduction of MITF expression. It suppresses melanogenesis in a zebrafish model. Kazinol U displays phytoestrogenic and anti-inflammatory activities. Kazinol U exhibits cytoprotective activities against cytokine-induced apoptotic cell death.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Qian Sun et al.
European journal of medicinal chemistry, 133, 1-10 (2017-04-04)
Enantiomers account for quite a large percentage of compounds in natural products. Our team is interested in the separation and biological activity of racemic compounds. In this report, four pairs of prenylated flavan enantiomers [(±)-1-(±)-4], including five new compounds, were
Ui-Jin Bae et al.
Biological & pharmaceutical bulletin, 34(7), 1026-1031 (2011-07-02)
The generation of nitric oxide (NO) via inducible NO synthase (iNOS) and reactive oxygen species plays a key role in cytokine-mediated pancreatic β-cell damage. Oxidative stress due to reactive oxygen species activates the nuclear factor-κB (NF-κB) transcription factor, which regulates
Jihyun Lim et al.
British journal of pharmacology, 176(5), 737-750 (2018-12-24)
Kazinol U is a prenylated flavan isolated from an extract of Broussonetia kazinoki Sieb (Moraceae). Kazinol U has shown cytoprotective effects against cytokine-induced apoptotic cell death and induces AMP kinase (AMPK) activation through LKB1 activation. However, kazinol U has not
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