SML3634
TRULI
≥98% (HPLC), YAP signaling activator, powder
别名:
N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
产品名称
TRULI, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CNC2=C1C=CC=N2)N=C3SC=CN3CC4=CC=CC=C4
InChI
1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)
InChI key
VTXBMVZVPUSAJF-UHFFFAOYSA-N
Biochem/physiol Actions
Cell penetrant, potent and non-toxic activator of Yap signaling; inhibitor of Lats kinases
TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) that induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable