SML3642
PD 173955
≥98% (HPLC)
别名:
6-(2,6-Dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, PD-173955
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C21H16Cl2N4OS
化学文摘社编号:
分子量:
443.35
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
SMILES string
S(C)c1cc(ccc1)Nc2nc3c(cn2)C=C(C(=O)N3C)c4c(cccc4Cl)Cl
InChI
1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
InChI key
VAARYSWULJUGST-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
PD 173955 is Tyrosine kinase inhibitor (TKI), which potently inhibits Bcr-Abl (IC50 = 1-2 nM), Src family kinase inhibitor specific for Src and Yes kinases (IC50 of 22 nM), and MAPK6/ERK3. According to IUPHAR/BPS Guide to PHARMACOLOGY PD 173955 is a best standard MAPK6 inhibitor pKD = 6.8
Tyrosine kinase type I inhibitor; potently inhibits Bcr-Abl and MAPK6/ERK3; Src family kinase inhibitor specific for Src and Yes kinases
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Anjana Sinha et al.
ACS medicinal chemistry letters, 10(10), 1430-1435 (2019-10-18)
Compound 3a, DV2-103, is a kinase inactive analogue of a potent Abl1/Src kinase inhibitor, PD173955, 2. Both compounds, 2 and 3a, are known to reduce production of beta amyloid (Aβ) peptide in cells and animal models. We have now prepared
Arjun Kumar Kalimuthu et al.
Scientific reports, 11(1), 21488-21488 (2021-11-04)
Spice-rich recipes are referred to as "functional foods" because they include a variety of bioactive chemicals that have health-promoting properties, in addition to their nutritional value. Using pharmacoinformatics-based analysis, we explored the relevance of bioactive chemicals found in Rasam (a
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持