质量水平
方案
≥98% (HPLC)
表单
powder
颜色
, Faint green to yellow
溶解性
DMSO: 2 mg/mL, clear (Warmed)
储存温度
2-8°C
SMILES字符串
n1c2c([o]c1c4ccccc4)C(=O)c3c(cccc3)C2=O
InChI
1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
InChI key
CMYQQADDUUDCCA-UHFFFAOYSA-N
生化/生理作用
SJB2-043 is a ubiquitin-specific protease USP1 inhibitor (IC50 = 544 nM using USP1/UAF1 complex) that exhibits anti-proliferation efficacy against chronic and acute myeloid leukemia lines (IC50 <2 µM; K562, OCI-AML3, SK-NO1, U937) and primary acute myelogenous leukemia (AML) patient-derived leukemic cells by promoting the degradation of transcription factor DNA binding 1 (ID1). SJB2-043 is also reported to be an allosteric site-targeting inhibitor against PLPro (IC50 = 0.56 μM), the papain-like cysteine protease with deubiquitination and deISGylation activities that suppress host innate immune responses toward SARS-CoV-2 infection.
Ubiquitin-specific protease USP1 inhibitor with anti-leukemia efficacy. Also reported to inhibit SARS-CoV-2 papain-like cysteine protease PLPro.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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