SML3681
ATM-3507
≥95% (HPLC)
别名:
ATM 3507, [3-[[2,3-Dimethyl-1-[3-(4-methyl-1-piperazinyl)propyl]-1H-indol-5-yl]oxy]phenyl][4-[2-(4-fluorophenyl)ethyl]-1-piperazinyl]-methanone
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关于此项目
经验公式（希尔记法）:
C37H46FN5O2
化学文摘社编号:
分子量:
611.79
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
ATM-3507, ≥95% (HPLC)
assay
≥95% (HPLC)
form
powder
color
, Colorless to light brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
ATM-3507 is a potent anti-tropomyosin agent that disables Tpm3.1 containing actin filaments. It exhibits potent cytotoxic activity against multiple neuroblastoma cancer cell lines. ATM-3507 sensitizes cancer cells to anti-microtubule agents. ATM-3507 significantly prolonged mitotic arrest induced by anti-microtubule agent vinorelbine.
Potent anti-tropomyosin agent that disables Tpm3.1 containing actin filaments
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs
Molecular Cancer Therapeutics, 16(8), 1555-1565 (2017)
Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1
Scientific Reports, 9(1), 11262-11262 (2019)
Xing Xu et al.
British journal of cancer, 125(2), 265-276 (2021-05-14)
Anti-microtubule agents are widely used to treat ovarian cancers, but the efficacy is often compromised by drug resistance. We investigated co-targeting the actin/tropomyosin cytoskeleton and microtubules to increase treatment efficacy in ovarian cancers and potentially overcome resistance. The presence of
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