SML3694
FR901464
≥95% (HPLC)
别名:
(2Z,4S)-4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-2-Pentenamide, FR 901464, WB 2663B
生化/生理作用
Inhibitor of pre-mRNA splicing; potent antitumor agent.
FR901464 is a potent anticancer agent isolated from the culture broth of the bacterium Pseudomonas sp. 2663. The compound binds to the splicing factor 3b complex and inhibits pre-mRNA splicing. FR901464 causes cell cycle arrest at the G1 and G2/M phases.
FR901464 is a potent anticancer agent isolated from the culture broth of the bacterium Pseudomonas sp. 2663. The compound binds to the splicing factor 3b complex and inhibits pre-mRNA splicing. FR901464 causes cell cycle arrest at the G1 and G2/M phases.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells
Molecular Cancer Therapeutics, 8(8), 2308-2318 (2009)
Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast
Biochemical and Biophysical Research Communications, 364(3), 573-577 (2007)
Splicing modulator FR901464 is a potential agent for colorectal cancer in combination therapy
Oncotarget, 10(3), 352-367 (2019)
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