SML3704
MRE-269
≥98% (HPLC)
别名:
2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid, ACT-333679, MRE 269, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C25H29N3O3
化学文摘社编号:
分子量:
419.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
MRE-269, ≥98% (HPLC)
SMILES string
N(C(C)C)(CCCCOCC(=O)O)c1nc(c(nc1)c3ccccc3)c2ccccc2
InChI
1S/C25H29N3O3/c1-19(2)28(15-9-10-16-31-18-23(29)30)22-17-26-24(20-11-5-3-6-12-20)25(27-22)21-13-7-4-8-14-21/h3-8,11-14,17,19H,9-10,15-16,18H2,1-2H3,(H,29,30)
InChI key
OJQMKCBWYCWFPU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
, White to light brown
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
MRE-269 (ACT-333679) is an active form of Selexipag (NS-304). MRE-269 is a potent and highly selective IP receptor agonist (selective PGI2 receptor agonist).
Potent and highly selective IP receptor agonist; selective PGI2 receptor agonist
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Hidekazu Maruyama et al.
Life sciences, 315, 121372-121372 (2023-01-08)
Upregulated p38MAPK signaling is implicated in the accelerated proliferation of pulmonary artery smooth muscle cells (PA-SMCs) and the pathogenesis of pulmonary artery remodeling observed in pulmonary arterial hypertension (PAH). Previously, we reported that after endothelin-1 (ET-1) pretreatment, bone morphogenetic protein
Samuel N Baldwin et al.
British journal of pharmacology, 179(7), 1338-1352 (2021-11-13)
Prostacyclin mimetics express potent vasoactive effects via prostanoid receptors that are not unequivocally defined, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of IP and EP3 prostanoid
Keith Morrison et al.
The Journal of pharmacology and experimental therapeutics, 335(1), 249-255 (2010-07-28)
Selexipag [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide] is an orally available prostacyclin (PGI(2)) receptor (IP receptor) agonist that is chemically distinct from PGI(2) and is in clinical development for the treatment of pulmonary arterial hypertension. Selexipag is highly selective for the human IP receptor in
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持